Hypoxanthine Induces Muscular ATP Depletion and Fatigue via UCP2

Hypoxanthine Induces Muscular ATP Depletion and Fatigue via UCP2

Hypoxanthine (Hx), an intermediate metabolite of the purine metabolism pathway which is dramatically increased in blood and skeletal muscle during muscle contraction and metabolism, is characterized as a marker of exercise exhaustion. However, the physiological effects of Hx on skeletal muscle remai...

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Bibliographic Details
Main Authors: Cong Yin, Zewei Ma, Fan Li, Chen Duan, Yexian Yuan, Canjun Zhu, Lina Wang, Xiaotong Zhu, Songbo Wang, Ping Gao, Gang Shu, Huihua Zhang, Qingyan Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Physiology
Subjects:
hypoxanthine
exercise
skeletal muscle
UCP2
ATP
fatigue
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.647743/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.647743/full

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