Natural variation in Vif: differential impact on APOBEC3G/3F and a potential role in HIV-1 diversification.
The HIV-1 Vif protein counteracts the antiviral activity exhibited by the host cytidine deaminases APOBEC3G and APOBEC3F. Here, we show that defective vif alleles can readily be found in HIV-1 isolates and infected patients. Single residue changes in the Vif protein sequence are sufficient to cause...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2005-09-01
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| Series: | PLoS Pathogens |
| Online Access: | http://europepmc.org/articles/PMC1238741?pdf=render |