Asymmetric Michael Addition in Synthesis of β-Substituted GABA Derivatives

Asymmetric Michael Addition in Synthesis of β-Substituted GABA Derivatives

γ-Aminobutyric acid (GABA) represents one of the most prolific structural units widely used in the design of modern pharmaceuticals. For example, β-substituted GABA derivatives are found in numerous neurological drugs, such as baclofen, phenibut, tolibut, pregabalin, phenylpiracetam, brivaracetam, a...

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Bibliographic Details
Main Authors: Jianlin Han, Jorge Escorihuela, Santos Fustero, Aitor Landa, Vadim A. Soloshonok, Alexander Sorochinsky
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Molecules
Subjects:
pharmaceuticals
neurological drugs
γ-aminobutyric-acid derivatives
asymmetric Michael addition
chiral auxiliaries
enantioselective organocatalysis
Online Access:https://www.mdpi.com/1420-3049/27/12/3797

Internet

https://www.mdpi.com/1420-3049/27/12/3797

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