Reduced Granule Cell Proliferation and Molecular Dysregulation in the Cerebellum of Lysosomal Acid Phosphatase 2 (ACP2) Mutant Mice

Reduced Granule Cell Proliferation and Molecular Dysregulation in the Cerebellum of Lysosomal Acid Phosphatase 2 (ACP2) Mutant Mice

Lysosomal acid phosphatase 2 (<i>Acp2</i>) mutant mice (naked-ataxia, <i>nax</i>) have a severe cerebellar cortex defect with a striking reduction in the number of granule cells. Using a combination of in vivo and in vitro immunohistochemistry, Western blotting, BrdU assays,...

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Bibliographic Details
Main Authors: Xiaodan Jiao, Maryam Rahimi Balaei, Ejlal Abu-El-Rub, Filippo Casoni, Hassan Pezeshgi Modarres, Sanjiv Dhingra, Jiming Kong, Giacomo G. Consalez, Hassan Marzban
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
granule cells
SHH
MYCN
cerebellum
mice
<i>nax</i>
Online Access:https://www.mdpi.com/1422-0067/22/6/2994

Internet

https://www.mdpi.com/1422-0067/22/6/2994

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