Oncostatin M Counteracts the Fibrotic Effects of TGF-β1 and IL-4 on Nasal-Polyp-Derived Fibroblasts: A Control of Fibrosis in Chronic Rhinosinusitis with Nasal Polyps?

Oncostatin M Counteracts the Fibrotic Effects of TGF-β1 and IL-4 on Nasal-Polyp-Derived Fibroblasts: A Control of Fibrosis in Chronic Rhinosinusitis with Nasal Polyps?

Chronic rhinosinusitis with nasal polyps (CRSwNP) is associated with inflammation and tissue remodeling including myofibroblasts differentiation and extracellular matrix (ECM) deposition mediated by TGF-β1 and IL-4. Oncostatin M (OSM) is a cytokine involved in fibrotic processes in other cellular su...

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Bibliographic Details
Main Authors: Florent Carsuzaa, Émilie Béquignon, Matthieu Bainaud, Jean-François Jégou, Xavier Dufour, Jean-Claude Lecron, Laure Favot
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:International Journal of Molecular Sciences
Subjects:
chronic rhinosinusitis
cytokines
inflammation
nasal polyps
fibroblasts
fibrosis
Online Access:https://www.mdpi.com/1422-0067/23/11/6308

Internet

https://www.mdpi.com/1422-0067/23/11/6308

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