How GRAIL controls Treg function to maintain self-tolerance

How GRAIL controls Treg function to maintain self-tolerance

Regulatory T cells (Tregs) normally maintain self-tolerance. Tregs recognize “self” such that when they are not working properly, such as in autoimmunity, the immune system can attack and destroy one’s own tissues. Current therapies for autoimmunity rely on relatively ineffective and too often toxic...

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Bibliographic Details
Main Authors: C. Garrison Fathman, Linda Yip, Diana Gómez-Martín, Mang Yu, Christine M. Seroogy, Clarence R. Hurt, Jack T. Lin, Jennifer A. Jenks, Kari C. Nadeau, Luis Soares
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
GRAIL
regulatory T cell
neddylation
cullin RING ligase
immune regulation
low dose IL-2
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1046631/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1046631/full

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