Using Human ‘Personalized’ Cybrids to Identify Drugs/Agents That Can Regulate Chronic Lymphoblastic Leukemia Mitochondrial Dysfunction

Using Human ‘Personalized’ Cybrids to Identify Drugs/Agents That Can Regulate Chronic Lymphoblastic Leukemia Mitochondrial Dysfunction

This study uses personalized chronic lymphoblastic leukemia (CLL) cybrid cells to test various drugs/agents designed to improve mitochondrial function and cell longevity. Age-matched control (NL) and CLL cybrids were created. The NL and CLL cybrids were treated with ibrutinib (Ibr-10 μM), mitochondr...

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Bibliographic Details
Main Authors: Lata Singh, Shari Atilano, Marilyn Chwa, Mithalesh K. Singh, Mustafa Ozgul, Anthony Nesburn, M. Cristina Kenney
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
chronic lymphoblastic leukemia
cybrid
mitochondria
nutraceutical
ibrutinib
Online Access:https://www.mdpi.com/1422-0067/24/13/11025

Internet

https://www.mdpi.com/1422-0067/24/13/11025

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