Different p53 genotypes regulating different phosphorylation sites and subcellular location of CDC25C associated with the formation of polyploid giant cancer cells

Different p53 genotypes regulating different phosphorylation sites and subcellular location of CDC25C associated with the formation of polyploid giant cancer cells

Abstract Background Our previous studies have confirmed that cobalt chloride (CoCl2) can induce the formation of polyploid giant cancer cells (PGCCs), which is the key to the heterogeneity of solid tumors. PGCC formation is closely related to the abnormal expression of cell cycle-related proteins an...

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Bibliographic Details
Main Authors: Kai Liu, Minying Zheng, Qi Zhao, Kexin Zhang, Zugui Li, Fangmei Fu, Hao Zhang, Jiaxing Du, Yuwei Li, Shiwu Zhang
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Polyploid giant cancer cells
Cell cycle-related proteins
Phosphorylation
CDC25C
p53
Online Access:http://link.springer.com/article/10.1186/s13046-020-01588-w

Internet

http://link.springer.com/article/10.1186/s13046-020-01588-w

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