Increased core body temperature exacerbates defective protein prenylation in mouse models of mevalonate kinase deficiency

Increased core body temperature exacerbates defective protein prenylation in mouse models of mevalonate kinase deficiency

Mevalonate kinase deficiency (MKD) is characterized by recurrent fevers and flares of systemic inflammation, caused by biallelic loss-of-function mutations in MVK. The underlying disease mechanisms and triggers of inflammatory flares are poorly understood because of the lack of in vivo models. We de...

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Bibliographic Details
Main Authors: Marcia A. Munoz, Oliver P. Skinner, Etienne Masle-Farquhar, Julie Jurczyluk, Ya Xiao, Emma K. Fletcher, Esther Kristianto, Mark P. Hodson, Seán I. O’Donoghue, Sandeep Kaur, Robert Brink, David G. Zahra, Elissa K. Deenick, Kristen A. Perry, Avril A.B. Robertson, Sam Mehr, Pravin Hissaria, Catharina M. Mulders-Manders, Anna Simon, Michael J. Rogers
Format: Article
Language:English
Published: American Society for Clinical Investigation 2022-10-01
Series:The Journal of Clinical Investigation
Subjects:
Inflammation
Metabolism
Online Access:https://doi.org/10.1172/JCI160929

Internet

https://doi.org/10.1172/JCI160929

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