The Effect of a Novel Serine Protease Inhibitor on Inflammation and Intestinal Permeability in a Murine Colitis Transfer Model

The Effect of a Novel Serine Protease Inhibitor on Inflammation and Intestinal Permeability in a Murine Colitis Transfer Model

Background: A protease/antiprotease disbalance is observed in inflammatory bowel diseases (IBD). We therefore studied the effect of the novel serine protease inhibitor UAMC-00050 on intestinal inflammation and permeability in a chronic colitis T cell transfer mouse model to get further insight into...

Full description

Bibliographic Details
Main Authors: Hanne Van Spaendonk, Hannah Ceuleers, Annemieke Smet, Maya Berg, Jurgen Joossens, Pieter Van der Veken, Sven M. Francque, Anne-Marie Lambeir, Joris G. De Man, Ingrid De Meester, Koen Augustyns, Benedicte Y. De Winter
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
T cell transfer colitis mouse model
serine protease inhibitor
intestinal barrier
T cells
protease-activated receptors
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.682065/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.682065/full

Similar Items