The Effect of a Novel Serine Protease Inhibitor on Inflammation and Intestinal Permeability in a Murine Colitis Transfer Model

The Effect of a Novel Serine Protease Inhibitor on Inflammation and Intestinal Permeability in a Murine Colitis Transfer Model

Background: A protease/antiprotease disbalance is observed in inflammatory bowel diseases (IBD). We therefore studied the effect of the novel serine protease inhibitor UAMC-00050 on intestinal inflammation and permeability in a chronic colitis T cell transfer mouse model to get further insight into...

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Bibliographic Details
Main Authors:	Hanne Van Spaendonk, Hannah Ceuleers, Annemieke Smet, Maya Berg, Jurgen Joossens, Pieter Van der Veken, Sven M. Francque, Anne-Marie Lambeir, Joris G. De Man, Ingrid De Meester, Koen Augustyns, Benedicte Y. De Winter
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-06-01
Series:	Frontiers in Pharmacology
Subjects:	T cell transfer colitis mouse model serine protease inhibitor intestinal barrier T cells protease-activated receptors
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2021.682065/full

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