Exploring the Mechanism of Danshensu in the Treatment of Doxorubicin-Induced Cardiotoxicity Based on Network Pharmacology and Experimental Evaluation

Exploring the Mechanism of Danshensu in the Treatment of Doxorubicin-Induced Cardiotoxicity Based on Network Pharmacology and Experimental Evaluation

BackgroundDoxorubicin (DOX) is one of the most effective chemotherapeutic agents available; however, its use is limited by the risk of serious cardiotoxicity. Danshensu (DSS), an active ingredient in Salvia miltiorrhiza, has multiple cardioprotective effects, but the effect of DSS on DOX-induced car...

Full description

Bibliographic Details
Main Authors: Jia-ying Qi, Ya-kun Yang, Chuan Jiang, Yang Zhao, Yong-chao Wu, Xue Han, Xuan Jing, Zhong-lin Wu, Li Chu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
Doxorubicin
Danshensu
network pharmacology
oxidative stress
inflammation
Keap1-Nrf2/NQO1
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.827975/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2022.827975/full

Similar Items