Ac-SDKP promotes KIF3A-mediated β-catenin suppression through a ciliary mechanism to constrain silica-induced epithelial-myofibroblast transition

Ac-SDKP promotes KIF3A-mediated β-catenin suppression through a ciliary mechanism to constrain silica-induced epithelial-myofibroblast transition

Kinesin family member 3 A (KIF3A) decrease have been reported in silicotic patients and rats. However, the detailed mechanisms of KIF3A in silicosis remain unknown. In this study, we demonstrated that KIF3A effectively blocked the expression of β-catenin and downstream myocardin-related transcriptio...

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Bibliographic Details
Main Authors: Shupeng Liu, Ruotong Jin, Gaigai Zheng, Yiyun Wang, Qian Li, Fuyu Jin, Yaqian Li, Tian Li, Na Mao, Zhongqiu Wei, Gengxu Li, Yuhang Fan, Hong Xu, Shifeng Li, Fang Yang
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Primary cilia
Kinesin family member 3A
N-acetyl-seryl-aspartyl-lysyl-proline
Epithelial−myofibroblast transition
Silicosis
Online Access:http://www.sciencedirect.com/science/article/pii/S075333222301209X

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http://www.sciencedirect.com/science/article/pii/S075333222301209X

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