A mouse anti-myostatin antibody increases muscle mass and improves muscle strength and contractility in the mdx mouse model of Duchenne muscular dystrophy and its humanized equivalent, domagrozumab (PF-06252616), increases muscle volume in cynomolgus monkeys

A mouse anti-myostatin antibody increases muscle mass and improves muscle strength and contractility in the mdx mouse model of Duchenne muscular dystrophy and its humanized equivalent, domagrozumab (PF-06252616), increases muscle volume in cynomolgus monkeys

Abstract Background The treatments currently approved for Duchenne muscular dystrophy (DMD), a progressive skeletal muscle wasting disease, address the needs of only a small proportion of patients resulting in an urgent need for therapies that benefit all patients regardless of the underlying mutati...

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Bibliographic Details
Main Authors: Michael St. Andre, Mark Johnson, Prashant N. Bansal, Jeremy Wellen, Andrew Robertson, Alan Opsahl, Peter M. Burch, Peter Bialek, Carl Morris, Jane Owens
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Skeletal Muscle
Subjects:
Myostatin
Hypertrophy
Skeletal muscle
Duchenne muscular dystrophy
Monoclonal antibody
mdx
Online Access:http://link.springer.com/article/10.1186/s13395-017-0141-y

Internet

http://link.springer.com/article/10.1186/s13395-017-0141-y

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