BK Channel in the Physiology and in the Cancer of Pancreatic Duct: Impact and Reliability of BK Openers

BK (KCa 1.1, Slo-1) is a K+ channel characterized by an allosteric regulation of the gating mechanism by Ca2+ binding and voltage, and a high unitary conductance. The channel is expressed in many different tissues, where it is involved in the regulation or the fine-tuning of many physiological proce...

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Bibliographic Details
Main Authors: Paolo Zuccolini, Paola Gavazzo, Michael Pusch
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.906608/full