White matter hyperintensities are more highly associated with preclinical Alzheimer's disease than imaging and cognitive markers of neurodegeneration
Abstract Introduction Cognitive tests and nonamyloid imaging biomarkers do not consistently identify preclinical AD. The objective of this study was to evaluate whether white matter hyperintensity (WMH) volume, a cerebrovascular disease marker, is more associated with preclinical AD than conventiona...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Subjects: | |
| Online Access: | https://doi.org/10.1016/j.dadm.2016.03.001 |
| _version_ | 1819148163163881472 |
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| author | Benjamin M. Kandel Brian B. Avants James C. Gee Corey T. McMillan Guray Erus Jimit Doshi Christos Davatzikos David A. Wolk Alzheimer's Disease Neuroimaging Initiative |
| author_facet | Benjamin M. Kandel Brian B. Avants James C. Gee Corey T. McMillan Guray Erus Jimit Doshi Christos Davatzikos David A. Wolk Alzheimer's Disease Neuroimaging Initiative |
| author_sort | Benjamin M. Kandel |
| collection | DOAJ |
| description | Abstract Introduction Cognitive tests and nonamyloid imaging biomarkers do not consistently identify preclinical AD. The objective of this study was to evaluate whether white matter hyperintensity (WMH) volume, a cerebrovascular disease marker, is more associated with preclinical AD than conventional AD biomarkers and cognitive tests. Methods Elderly controls enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI, n = 158) underwent florbetapir‐PET scans, psychometric testing, neuroimaging with MRI and PET, and APOE genetic testing. Elderly controls the Parkinson's progression markers initiative (PPMI, n = 58) had WMH volume, cerebrospinal fluid (CSF) Aβ1–42, and APOE status measured. Results In the ADNI cohort, only WMH volume and APOE ε4 status were associated with cerebral Aβ (standardized β = 0.44 and 1.25, P = .03 and .002). The association between WMH volume and APOE ε4 status with cerebral Aβ (standardized β = 1.12 and 0.26, P = .048 and .045) was confirmed in the PPMI cohort. Discussion WMH volume is more highly associated with preclinical AD than other AD biomarkers. |
| first_indexed | 2024-12-22T13:41:20Z |
| format | Article |
| id | doaj.art-21bde459d6a8424bb696b09dda2dd809 |
| institution | Directory Open Access Journal |
| issn | 2352-8729 |
| language | English |
| last_indexed | 2024-12-22T13:41:20Z |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj.art-21bde459d6a8424bb696b09dda2dd8092022-12-21T18:23:55ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292016-01-0141182710.1016/j.dadm.2016.03.001White matter hyperintensities are more highly associated with preclinical Alzheimer's disease than imaging and cognitive markers of neurodegenerationBenjamin M. Kandel0Brian B. Avants1James C. Gee2Corey T. McMillan3Guray Erus4Jimit Doshi5Christos Davatzikos6David A. Wolk7Alzheimer's Disease Neuroimaging Initiative8Penn Image Computing and Science Laboratory and Department of BioengineeringUniversity of PennsylvaniaPhiladelphiaPAUSAPenn Image Computing and Science Laboratory and Department of RadiologyPerelman School of Medicine, University of PennsylvaniaPhiladelphiaPAUSAPenn Image Computing and Science Laboratory and Department of RadiologyPerelman School of Medicine, University of PennsylvaniaPhiladelphiaPAUSADepartment of NeurologyPerelman School of Medicine, University of PennsylvaniaPhiladelphiaPAUSACenter for Biomedical Image Computing and Analytics, University of PennsylvaniaPhiladelphiaPACenter for Biomedical Image Computing and Analytics, University of PennsylvaniaPhiladelphiaPACenter for Biomedical Image Computing and Analytics, University of PennsylvaniaPhiladelphiaPADepartment of NeurologyPerelman School of Medicine, University of PennsylvaniaPhiladelphiaPAUSAPenn Image Computing and Science Laboratory and Department of BioengineeringUniversity of PennsylvaniaPhiladelphiaPAUSAAbstract Introduction Cognitive tests and nonamyloid imaging biomarkers do not consistently identify preclinical AD. The objective of this study was to evaluate whether white matter hyperintensity (WMH) volume, a cerebrovascular disease marker, is more associated with preclinical AD than conventional AD biomarkers and cognitive tests. Methods Elderly controls enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI, n = 158) underwent florbetapir‐PET scans, psychometric testing, neuroimaging with MRI and PET, and APOE genetic testing. Elderly controls the Parkinson's progression markers initiative (PPMI, n = 58) had WMH volume, cerebrospinal fluid (CSF) Aβ1–42, and APOE status measured. Results In the ADNI cohort, only WMH volume and APOE ε4 status were associated with cerebral Aβ (standardized β = 0.44 and 1.25, P = .03 and .002). The association between WMH volume and APOE ε4 status with cerebral Aβ (standardized β = 1.12 and 0.26, P = .048 and .045) was confirmed in the PPMI cohort. Discussion WMH volume is more highly associated with preclinical AD than other AD biomarkers.https://doi.org/10.1016/j.dadm.2016.03.001Alzheimer's diseaseAgingMRIPETWhite matterLeukoaraiosis |
| spellingShingle | Benjamin M. Kandel Brian B. Avants James C. Gee Corey T. McMillan Guray Erus Jimit Doshi Christos Davatzikos David A. Wolk Alzheimer's Disease Neuroimaging Initiative White matter hyperintensities are more highly associated with preclinical Alzheimer's disease than imaging and cognitive markers of neurodegeneration Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring Alzheimer's disease Aging MRI PET White matter Leukoaraiosis |
| title | White matter hyperintensities are more highly associated with preclinical Alzheimer's disease than imaging and cognitive markers of neurodegeneration |
| title_full | White matter hyperintensities are more highly associated with preclinical Alzheimer's disease than imaging and cognitive markers of neurodegeneration |
| title_fullStr | White matter hyperintensities are more highly associated with preclinical Alzheimer's disease than imaging and cognitive markers of neurodegeneration |
| title_full_unstemmed | White matter hyperintensities are more highly associated with preclinical Alzheimer's disease than imaging and cognitive markers of neurodegeneration |
| title_short | White matter hyperintensities are more highly associated with preclinical Alzheimer's disease than imaging and cognitive markers of neurodegeneration |
| title_sort | white matter hyperintensities are more highly associated with preclinical alzheimer s disease than imaging and cognitive markers of neurodegeneration |
| topic | Alzheimer's disease Aging MRI PET White matter Leukoaraiosis |
| url | https://doi.org/10.1016/j.dadm.2016.03.001 |
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