Catalytic enantioselective addition of Grignard reagents to aromatic silyl ketimines
The stereoselective addition of Grignard reagents to ketimines is potentially a straightforward route to α-chiral amines. Here the authors report a catalytic, asymmetric Grignard addition to silyl ketimines, givingN-sulfonyl protected α-chiral silyl amines with tetrasubstituted stereocentres.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13780 |