Nuclear factor erythroid 2–related factor 2 (Nrf2) deficiency causes age-dependent progression of female osteoporosis

Abstract Background Nuclear factor erythroid 2–related factor 2 (Nrf2) is a crucial transcription factor for cellular redox homeostasis. The association of Nrf2 with elderly female osteoporotic has yet to be fully described. The aim was to elucidate a potential age-dependent Nrf2 contribution to fem...

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Main Authors: Yusuke Kubo, Jesus Abraham Herrera Gonzalez, Rainer Beckmann, Marek Weiler, Helda Pahlavani, Mauricio Cruz Saldivar, Katharina Szymanski, Stefanie Rosenhain, Athanassios Fragoulis, Sander Leeflang, Alexander Slowik, Felix Gremse, Michael Wolf, Mohammad Javad Mirzaali, Amir Abbas Zadpoor, Christoph Jan Wruck, Thomas Pufe, Mersedeh Tohidnezhad, Holger Jahr
Format: Article
Language:English
Published: BMC 2022-11-01
Series:BMC Musculoskeletal Disorders
Subjects:
Online Access:https://doi.org/10.1186/s12891-022-05942-1