rhBMP-2 induces terminal differentiation of human bone marrow mesenchymal stromal cells only by synergizing with other signals

rhBMP-2 induces terminal differentiation of human bone marrow mesenchymal stromal cells only by synergizing with other signals

Abstract Background Recombinant human bone morphogenetic protein 2 (rhBMP-2) and human bone marrow mesenchymal stromal cells (hBM-MSCs) have been thoroughly studied for research and translational bone regeneration purposes. rhBMP-2 induces bone formation in vivo, and hBM-MSCs are its target, bone-fo...

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Bibliographic Details
Main Authors: Neda Kathami, Carolina Moreno-Vicente, Pablo Martín, Jhonatan A. Vergara-Arce, Raquel Ruiz-Hernández, Daniela Gerovska, Ana M. Aransay, Marcos J. Araúzo-Bravo, Sandra Camarero-Espinosa, Ander Abarrategi
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Stem Cell Research & Therapy
Subjects:
rhBMP-2
Mesenchymal stem cells
Differentiation
Osteogenesis
Chondrogenesis
Adipogenesis
Online Access:https://doi.org/10.1186/s13287-024-03735-y

Internet

https://doi.org/10.1186/s13287-024-03735-y

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