Amantadine Combines Astroglial System Xc<sup>−</sup> Activation with Glutamate/NMDA Receptor Inhibition

Amantadine Combines Astroglial System Xc<sup>−</sup> Activation with Glutamate/NMDA Receptor Inhibition

A glutamate/NMDA receptor (NMDA-R) antagonist, amantadine (AMA) exhibits a broad spectrum of clinically important properties, including antiviral, antiparkinsonian, neuroprotective, neuro-reparative and cognitive-enhancing effects. However, both clinical and pre-clinical studies have demonstrated th...

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Bibliographic Details
Main Authors: Tomosuke Nakano, Toshiki Hasegawa, Dai Suzuki, Eishi Motomura, Motohiro Okada
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Biomolecules
Subjects:
amantadine
system xc<sup>−</sup>
L-glutamate
glutathione
astrocyte
Online Access:https://www.mdpi.com/2218-273X/9/5/191

Internet

https://www.mdpi.com/2218-273X/9/5/191

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