MAF1, a repressor of RNA polymerase III-dependent transcription, regulates bone mass

MAF1, a repressor of RNA polymerase III-dependent transcription, regulates bone mass

MAF1, a key repressor of RNA polymerase (pol) III-mediated transcription, has been shown to promote mesoderm formation in vitro. Here, we show that MAF1 plays a critical role in regulating osteoblast differentiation and bone mass. Global deletion of MAF1 (Maf1-/- mice) produced a high bone mass phen...

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Bibliographic Details
Main Authors: Ellen Phillips, Naseer Ahmad, Li Sun, James Iben, Christopher J Walkey, Aleksandra Rusin, Tony Yuen, Clifford J Rosen, Ian M Willis, Mone Zaidi, Deborah L Johnson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-05-01
Series:eLife
Subjects:
bone mass
RNA polymerase III
MAF1
osteoblast
Online Access:https://elifesciences.org/articles/74740

Internet

https://elifesciences.org/articles/74740

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