Post-translational modification of CDK1–STAT3 signaling by fisetin suppresses pancreatic cancer stem cell properties

Post-translational modification of CDK1–STAT3 signaling by fisetin suppresses pancreatic cancer stem cell properties

Abstract Background Pancreatic cancer stem cells (CSCs) promote pancreatic ductal adenocarcinoma (PDAC) tumorigenesis and chemoresistance. Cyclin-dependent kinase 1 (CDK1) plays an important role in tumor initiation in other tumors, but the function of CDK1 in PDAC remains unclear. Fisetin is a bioa...

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Bibliographic Details
Main Authors: Xiaodong Xu, Yimin Ding, Junbin Jin, Chengjie Xu, Wenyi Hu, Songtao Wu, Guoping Ding, Rui Cheng, Liping Cao, Shengnan Jia
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Cell & Bioscience
Subjects:
CDK1
Fisetin
Cancer stem cells
STAT3
Pancreatic ductal adenocarcinoma
Online Access:https://doi.org/10.1186/s13578-023-01118-z

Internet

https://doi.org/10.1186/s13578-023-01118-z

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