Are non-constant rates and non-proportional treatment effects accounted for in the design and analysis of randomised controlled trials? A review of current practice

Are non-constant rates and non-proportional treatment effects accounted for in the design and analysis of randomised controlled trials? A review of current practice

Abstract Background Most clinical trials with time-to-event primary outcomes are designed assuming constant event rates and proportional hazards over time. Non-constant event rates and non-proportional hazards are seen increasingly frequently in trials. The objectives of this review were firstly to...

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Bibliographic Details
Main Authors: Kim Jachno, Stephane Heritier, Rory Wolfe
Format: Article
Language:English
Published: BMC 2019-05-01
Series:BMC Medical Research Methodology
Subjects:
Randomised controlled trial
Time-to-event outcome
Proportional hazards
Event rates
Trial reporting
Sample size calculation
Online Access:http://link.springer.com/article/10.1186/s12874-019-0749-1

Internet

http://link.springer.com/article/10.1186/s12874-019-0749-1

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