Integration of the Deacetylase SIRT1 in the Response to Nucleolar Stress: Metabolic Implications for Neurodegenerative Diseases

Integration of the Deacetylase SIRT1 in the Response to Nucleolar Stress: Metabolic Implications for Neurodegenerative Diseases

Understanding underlying mechanisms of neurodegenerative diseases is fundamental to develop effective therapeutic intervention. Yet they remain largely elusive, but metabolic, and transcriptional dysregulation are common events. Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-depende...

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Bibliographic Details
Main Authors: Grzegorz Kreiner, Aynur Sönmez, Birgit Liss, Rosanna Parlato
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
sirtuin
oxidative stress
nucleolus
rRNA
p53
neuronal homeostasis
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00106/full

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https://www.frontiersin.org/article/10.3389/fnmol.2019.00106/full

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