Dysregulation of MITF Leads to Transformation in MC1R-Defective Melanocytes

Dysregulation of MITF Leads to Transformation in MC1R-Defective Melanocytes

The MC1R/cAMP/MITF pathway is a key determinant for growth, differentiation, and survival of melanocytes and melanoma. MITF-M is the melanocyte-specific isoform of Microphthalmia-associated Transcription Factor (MITF) in human melanoma. Here we use two melanocyte cell lines to show that forced expre...

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Bibliographic Details
Main Authors: Timothy J. Lavelle, Tine Norman Alver, Karen-Marie Heintz, Patrik Wernhoff, Vegard Nygaard, Sigve Nakken, Geir Frode Øy, Sigurd Leinæs Bøe, Alfonso Urbanucci, Eivind Hovig
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cancers
Subjects:
melanoma
melanocyte transformation
MITF
MC1R
AXL inhibitor
familial melanoma
Online Access:https://www.mdpi.com/2072-6694/12/7/1719

Internet

https://www.mdpi.com/2072-6694/12/7/1719

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