Interferon Lambda Signals in Maternal Tissues to Exert Protective and Pathogenic Effects in a Gestational Stage-Dependent Manner
ABSTRACT Interferon lambda (IFN-λ) (type III IFN) is constitutively secreted from human placental cells in culture and reduces Zika virus (ZIKV) transplacental transmission in mice. However, the roles of IFN-λ during healthy pregnancy and in restricting congenital infection remain unclear. Here, we...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
American Society for Microbiology
2022-06-01
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Series: | mBio |
Subjects: | |
Online Access: | https://journals.asm.org/doi/10.1128/mbio.03857-21 |