Interferon Lambda Signals in Maternal Tissues to Exert Protective and Pathogenic Effects in a Gestational Stage-Dependent Manner

Interferon Lambda Signals in Maternal Tissues to Exert Protective and Pathogenic Effects in a Gestational Stage-Dependent Manner

ABSTRACT Interferon lambda (IFN-λ) (type III IFN) is constitutively secreted from human placental cells in culture and reduces Zika virus (ZIKV) transplacental transmission in mice. However, the roles of IFN-λ during healthy pregnancy and in restricting congenital infection remain unclear. Here, we...

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Bibliographic Details
Main Authors: Rebecca L. Casazza, Drake T. Philip, Helen M. Lazear
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:mBio
Subjects:
IFN
IFN-λ
interferon
Zika virus
congenital infection
pregnancy
Online Access:https://journals.asm.org/doi/10.1128/mbio.03857-21

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