Guanine inhibits the growth of human glioma and melanoma cell lines by interacting with GPR23

Guanine inhibits the growth of human glioma and melanoma cell lines by interacting with GPR23

Guanine-based purines (GBPs) exert numerous biological effects at the central nervous system through putative membrane receptors, the existence of which is still elusive. To shed light on this question, we screened orphan and poorly characterized G protein-coupled receptors (GPRs), selecting those t...

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Bibliographic Details
Main Authors: Roberta Garozzo, Mariachiara Zuccarini, Patricia Giuliani, Valentina Di Liberto, Giuseppa Mudò, Francesco Caciagli, Renata Ciccarelli, Francisco Ciruela, Patrizia Di Iorio, Daniele F. Condorelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
guanine-based purines (GBPs)
guanine (GUA)
purine nucleoside phosphorylase (PNP)
antiproliferative effects
G protein-coupled receptor 23 (GPR23)
glioma cell lines
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.970891/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.970891/full

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