Identification and quantification of defective virus genomes in high throughput sequencing data using DVG-profiler, a novel post-sequence alignment processing algorithm.

Identification and quantification of defective virus genomes in high throughput sequencing data using DVG-profiler, a novel post-sequence alignment processing algorithm.

Most viruses are known to spontaneously generate defective viral genomes (DVG) due to errors during replication. These DVGs are subgenomic and contain deletions that render them unable to complete a full replication cycle in the absence of a co-infecting, non-defective helper virus. DVGs, especially...

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Bibliographic Details
Main Authors: Trent J Bosma, Konstantinos Karagiannis, Luis Santana-Quintero, Natalia Ilyushina, Tatiana Zagorodnyaya, Svetlana Petrovskaya, Majid Laassri, Raymond P Donnelly, Steven Rubin, Vahan Simonyan, Christian J Sauder
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0216944

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https://doi.org/10.1371/journal.pone.0216944

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