Upregulation of TREM2 Ameliorates Neuroinflammatory Responses and Improves Cognitive Deficits Triggered by Surgical Trauma in Appswe/PS1dE9 Mice

Upregulation of TREM2 Ameliorates Neuroinflammatory Responses and Improves Cognitive Deficits Triggered by Surgical Trauma in Appswe/PS1dE9 Mice

Background/Aims: TREM2 plays a crucial role in modulating microglial function through interaction with DAP12, the adapter for TREM2. Emerging evidence has demonstrated that TREM2 could suppress neuroinflammatory responses by repression of microglia-mediated cytokine production. This study investigat...

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Bibliographic Details
Main Authors: Yanhua Jiang, Zhe Li, Hong Ma, Xuezhao Cao, Fang Liu, Ayong Tian, Xijia Sun, Xiaoqian Li, Jun Wang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-04-01
Series:Cellular Physiology and Biochemistry
Subjects:
Trem2
Microglia
Cytokines
Hippocampus
Neuroinflammation
Postoperative Cognitive Dysfunction (POCD)
Online Access:https://www.karger.com/Article/FullText/489155

Internet

https://www.karger.com/Article/FullText/489155

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