SNHG17 alters anaerobic glycolysis by resetting phosphorylation modification of PGK1 to foster pro-tumor macrophage formation in pancreatic ductal adenocarcinoma

SNHG17 alters anaerobic glycolysis by resetting phosphorylation modification of PGK1 to foster pro-tumor macrophage formation in pancreatic ductal adenocarcinoma

Abstract Background Within the tumor immune microenvironment (TME), tumor-associated macrophages (TAMs) are crucial in modulating polarization states to influence cancer development through metabolic reprogramming. While long non-coding RNAs (lncRNAs) have been shown to play a pivotal role in the pr...

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Bibliographic Details
Main Authors: Jiayu Lin, Yihao Liu, Pengyi Liu, Wenxin Qi, Jia Liu, Xingfeng He, Qian Liu, Zehua Liu, Jingxin Yin, Jiewei Lin, Haili Bao, Jianhong Lin
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
TAMs
PDAC
SNHG17
Anaerobic glycolysis
miR-628-5p
PGK1
Online Access:https://doi.org/10.1186/s13046-023-02890-z

Internet

https://doi.org/10.1186/s13046-023-02890-z

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