Single-use membrane adsorbers for endotoxin removal and purification of endogenous polysialic acid from Escherichia coli K1

Single-use membrane adsorbers for endotoxin removal and purification of endogenous polysialic acid from Escherichia coli K1

Polysialic acid (polySia) is a promising molecule for various medical applications (e.g., treatment of inflammatory neurodegenerative diseases). In this study a complete production process for human-identical α-(2,8)-linked polySia was developed using a disposable bioreactor for cultivation of Esche...

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Bibliographic Details
Main Authors: Ingo de Vries, Sarah Schreiber, Daniel Boßmann, Zawadi Hellmann, Jens Kopatz, Harald Neumann, Sascha Beutel
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Biotechnology Reports
Subjects:
Escherichia coli K1
Endotoxin
Membrane adsorber
Polysialic acid
Single-use
Online Access:http://www.sciencedirect.com/science/article/pii/S2215017X18300195

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http://www.sciencedirect.com/science/article/pii/S2215017X18300195

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