Neuroprotection from protein misfolding in cerebral hypoperfusion concurrent with metabolic syndrome. A translational perspective

Neuroprotection from protein misfolding in cerebral hypoperfusion concurrent with metabolic syndrome. A translational perspective

Based on clinical and experimental evidence, metabolic syndrome (MetS) and type 2 diabetes (T2D) are considered risk factors for chronic cerebral hypoperfusion (CCH) and neurodegeneration. Scientific evidence suggests that protein misfolding is a potential mechanism that explains how CCH can lead to...

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Bibliographic Details
Main Authors: Sofía Bordet, Juan Pablo Luaces, Maria Ines Herrera, Liliana Mirta Gonzalez, Tamara Kobiec, Santiago Perez-Lloret, Matilde Otero-Losada, Francisco Capani
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Neuroscience
Subjects:
metabolic syndrome
type 2 diabetes
chronic cerebral hypoperfusion
protein misfolding
neurodegeneration
animal models
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1215041/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2023.1215041/full

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