Serum indoxyl sulfate concentrations associate with progression of chronic kidney disease in children.

Serum indoxyl sulfate concentrations associate with progression of chronic kidney disease in children.

The uremic toxins indoxyl sulfate (IS) and p-cresyl sulfate (pCS) accumulate in patients with chronic kidney disease (CKD) as a consequence of altered gut microbiota metabolism and a decline in renal excretion. Despite of solid experimental evidence for nephrotoxic effects, the impact of uremic toxi...

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Main Authors: Johannes Holle, Marietta Kirchner, Jürgen Okun, Aysun K Bayazit, Lukasz Obrycki, Nur Canpolat, Ipek Kaplan Bulut, Karolis Azukaitis, Ali Duzova, Bruno Ranchin, Rukshana Shroff, Cengiz Candan, Jun Oh, Günter Klaus, Francesca Lugani, Charlotte Gimpel, Rainer Büscher, Alev Yilmaz, Esra Baskin, Hakan Erdogan, Ariane Zaloszyc, Gül Özcelik, Dorota Drozdz, Augustina Jankauskiene, Francois Nobili, Anette Melk, Uwe Querfeld, Franz Schaefer, 4C Study Consortium
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0240446

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https://doi.org/10.1371/journal.pone.0240446

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