SETD2 variation correlates with tumor mutational burden and MSI along with improved response to immunotherapy

SETD2 variation correlates with tumor mutational burden and MSI along with improved response to immunotherapy

Abstract Background SETD2 protects against genomic instability via maintenance of homologous recombination repair (HRR) and mismatch repair (MMR) in neoplastic cells. However, it remains unclear whether SETD2 dysfunction is a complementary or independent factor to microsatellite instability-high (MS...

Full description

Bibliographic Details
Main Authors: Xiaobin Zheng, Jing Lin, Jiani Xiong, Yanfang Guan, Bin Lan, Yi Li, Xuan Gao, Zhaodong Fei, Lisha Chen, Lizhu Chen, Ling Chen, Gang Chen, Zengqing Guo, Xin Yi, Weiguo Cao, Xinghao Ai, Chengzhi Zhou, Xiaofeng Li, Jun Zhao, Xiangtao Yan, Qitao Yu, Lu Si, Yu Chen, Chuanben Chen
Format: Article
Language:English
Published: BMC 2023-07-01
Series:BMC Cancer
Subjects:
Immune checkpoint inhibitors
Tumor mutation burden
Microsatellite instability
Tumor microenvironment
SETD2 mutation
Online Access:https://doi.org/10.1186/s12885-023-10920-4

Internet

https://doi.org/10.1186/s12885-023-10920-4

Similar Items