Altered lipid metabolites accelerate early dysfunction of T cells in HIV-infected rapid progressors by impairing mitochondrial function

Altered lipid metabolites accelerate early dysfunction of T cells in HIV-infected rapid progressors by impairing mitochondrial function

The complex mechanism of immune-system damage in HIV infection is incompletely understood. HIV-infected “rapid progressors” (RPs) have severe damage to the immune system early in HIV infection, which provides a “magnified” opportunity to study the interaction between HIV and the immune system. In th...

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Bibliographic Details
Main Authors: Si-Yao Li, Lin-Bo Yin, Hai-Bo Ding, Mei Liu, Jun-Nan Lv, Jia-Qi Li, Jing Wang, Tian Tang, Ya-Jing Fu, Yong-Jun Jiang, Zi-Ning Zhang, Hong Shang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
HIV rapid progression
immunometabolism
metabolomics
lipid metabolites
T-cell dysfunction
mitochondrial ROS
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1106881/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1106881/full

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