Oscillatory Deficits in the Sub-Chronic PCP Rat Model for Schizophrenia Are Reversed by mGlu5 Receptor-Positive Allosteric Modulators VU0409551 and VU0360172

Oscillatory Deficits in the Sub-Chronic PCP Rat Model for Schizophrenia Are Reversed by mGlu5 Receptor-Positive Allosteric Modulators VU0409551 and VU0360172

The cognitive deficits of schizophrenia are linked to imbalanced excitatory and inhibitory signalling in the prefrontal cortex (PFC), disrupting gamma oscillations. We previously demonstrated that two mGlu5 receptor-positive allosteric modulators (PAMs), VU0409551 and VU0360172, restore cognitive de...

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Bibliographic Details
Main Authors: Jessica Brown, Ben Grayson, Joanna C. Neill, Michael Harte, Mark J. Wall, Richard T. Ngomba
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Cells
Subjects:
metabotropic glutamate receptor
allosteric modulators
intracellular signalling
VU0409551
VU0360172
gamma oscillations
Online Access:https://www.mdpi.com/2073-4409/12/6/919

Internet

https://www.mdpi.com/2073-4409/12/6/919

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