Evolutionary and reverse engineering in Saccharomyces cerevisiae reveals a Pdr1p mutation-dependent mechanism for 2-phenylethanol tolerance

Evolutionary and reverse engineering in Saccharomyces cerevisiae reveals a Pdr1p mutation-dependent mechanism for 2-phenylethanol tolerance

Abstract Background 2-Phenylethanol (2-PE), a higher alcohol with a rose-like odor, inhibits growth of the producer strains. However, the limited knowledge regarding 2-PE tolerance mechanisms renders our current knowledge base insufficient to inform rational design. Results To improve the growth phe...

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Bibliographic Details
Main Authors: Huili Xia, Yue Kang, Zilin Ma, Cuiyu Hu, Qiao Yang, Xiaoling Zhang, Shihui Yang, Jun Dai, Xiong Chen
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Microbial Cell Factories
Subjects:
Adaptive laboratory evolution
Whole genome sequencing
2-Phenylethanol tolerance
Pdr1p mutation
Online Access:https://doi.org/10.1186/s12934-022-01996-x

Internet

https://doi.org/10.1186/s12934-022-01996-x

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