Lack of Functional Trehalase Activity in <i>Candida parapsilosis</i> Increases Susceptibility to Itraconazole

Lack of Functional Trehalase Activity in <i>Candida parapsilosis</i> Increases Susceptibility to Itraconazole

Central metabolic pathways may play a major role in the virulence of pathogenic fungi. Here, we have investigated the susceptibility of a <i>Candida parapsilosis</i> mutant deficient in trehalase activity (<i>atc1</i>Δ/<i>ntc1</i>Δ strain) to the azolic compounds...

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Bibliographic Details
Main Authors: Ruth Sánchez-Fresneda, María Luz Muñoz-Megías, Genoveva Yagüe, Francisco Solano, Sergi Maicas, Juan Carlos Argüelles
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Journal of Fungi
Subjects:
fluconazole
itraconazole
ROS
mitochondrial activity
trehalase
trehalose
Online Access:https://www.mdpi.com/2309-608X/8/4/371

Internet

https://www.mdpi.com/2309-608X/8/4/371

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