Metformin attenuates chronic lung allograft dysfunction: evidence in rat models

Metformin attenuates chronic lung allograft dysfunction: evidence in rat models

Abstract Background Chronic lung allograft dysfunction (CLAD) directly causes an abysmal long-term prognosis after lung transplantation (LTx), but effective and safe drugs are not available. Metformin exhibits high therapeutic potential due to its antifibrotic and immunomodulatory effects; however,...

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Bibliographic Details
Main Authors: Dong Tian, Xiangyun Zheng, Hongtao Tang, Heng Huang, Junjie Wang, Lin Xu, Caihan Li, Haoji Yan, Ruixuan Yu, Jinzhu Nan, Menggen Liu, Xiaoguang Guo, Shunhai Jian, Tao Wang, Senyi Deng, Qiang Pu, Lunxu Liu
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Respiratory Research
Subjects:
Metformin
Lung transplantation
Chronic lung allograft rejection
Chronic lung allograft dysfunction
AMP-activated kinase
Online Access:https://doi.org/10.1186/s12931-023-02492-5

Internet

https://doi.org/10.1186/s12931-023-02492-5

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