Probiotics suppress nonalcoholic steatohepatitis and carcinogenesis progression in hepatocyte-specific PTEN knockout mice

Abstract Nonalcoholic fatty liver disease (NAFLD), a hepatic characteristic of metabolic syndrome, received significant attention in clinical settings. The multiple-hit theory is one of the proposed mechanisms of NAFLD, and gut dysbiosis is considered a hit. Thus, controlling gut microbiota is a pot...

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Bibliographic Details
Main Authors: Naoshi Arai, Kouichi Miura, Kenichi Aizawa, Mariko Sekiya, Manabu Nagayama, Hirotsugu Sakamoto, Hiroshi Maeda, Naoki Morimoto, Sadahiko Iwamoto, Hironori Yamamoto
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-20296-3