The histone methyltransferase Setd8 alters the chromatin landscape and regulates the expression of key transcription factors during erythroid differentiation

The histone methyltransferase Setd8 alters the chromatin landscape and regulates the expression of key transcription factors during erythroid differentiation

Abstract Background SETD8 is the sole methyltransferase capable of mono-methylating histone H4, lysine 20. SETD8 and H4K20me1 play a role in a number of essential biologic processes, including cell cycle progression, establishment of higher order chromatin structure, and transcriptional regulation....

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Bibliographic Details
Main Authors: Jacquelyn A. Myers, Tyler Couch, Zachary Murphy, Jeffrey Malik, Michael Getman, Laurie A. Steiner
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Epigenetics & Chromatin
Subjects:
Erythroid
Setd8
H4K20me1
Chromatin
Differentiation
Online Access:http://link.springer.com/article/10.1186/s13072-020-00337-9

Internet

http://link.springer.com/article/10.1186/s13072-020-00337-9

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