BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function
Tumor suppressor p53 is the most frequently mutated gene in tumors. Many mutant p53 (mutp53) proteins promote tumorigenesis through the gain-of-function (GOF) mechanism. Mutp53 proteins often accumulate to high levels in tumors, which is critical for mutp53 GOF. Its underlying mechanism is poorly un...
Main Authors: | , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2015-08-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/08401 |