Fine pathogen discrimination within the APL1 gene family protects Anopheles gambiae against human and rodent malaria species.

Genetically controlled resistance of Anopheles gambiae mosquitoes to Plasmodium falciparum is a common trait in the natural population, and a cluster of natural resistance loci were mapped to the Plasmodium-Resistance Island (PRI) of the A. gambiae genome. The APL1 family of leucine-rich repeat (LRR...

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Bibliographic Details
Main Authors: Christian Mitri, Jean-Claude Jacques, Isabelle Thiery, Michelle M Riehle, Jiannong Xu, Emmanuel Bischoff, Isabelle Morlais, Sandrine E Nsango, Kenneth D Vernick, Catherine Bourgouin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-09-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2734057?pdf=render