Determination of Histidine Protonation States in Proteins by Fast Magic Angle Spinning NMR

Determination of Histidine Protonation States in Proteins by Fast Magic Angle Spinning NMR

Histidine residues play important structural and functional roles in proteins, such as serving as metal-binding ligands, mediating enzyme catalysis, and modulating proton channel activity. Many of these activities are modulated by the ionization state of the imidazole ring. Here we present a fast MA...

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Bibliographic Details
Main Authors: Roman Zadorozhnyi, Sucharita Sarkar, Caitlin M. Quinn, Kaneil K. Zadrozny, Barbie K. Ganser-Pornillos, Owen Pornillos, Angela M. Gronenborn, Tatyana Polenova
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Molecular Biosciences
Subjects:
Magic angle spinning (MAS)
nuclear magnetic resonance (NMR) spectroscopy
histidine protonation state
transferred echo double resonance (TEDOR)
Fast MAS NMR
solid-state NMR
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.767040/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.767040/full

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