Molecular epidemiological study of germline APC variant associated with hereditary gastrointestinal polyposis in dogs: current frequency in Jack Russell Terriers in Japan and breed distribution

Molecular epidemiological study of germline APC variant associated with hereditary gastrointestinal polyposis in dogs: current frequency in Jack Russell Terriers in Japan and breed distribution

Abstract Background Cases of gastrointestinal (GI) neoplastic polyps in Jack Russell Terriers (JRTs) have increased in Japan since the late 2000s. We recently demonstrated that JRTs with GI polyps heterozygously harbor an identical germline variant in the adenomatous polyposis coli (APC) gene, c.[46...

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Bibliographic Details
Main Authors: Kyoko Yoshizaki, Akihiro Hirata, Hiroyuki Matsushita, Masahiro Sakaguchi, Wakana Yoneji, Keishi Owaki, Hiroki Sakai
Format: Article
Language:English
Published: BMC 2022-06-01
Series:BMC Veterinary Research
Subjects:
Hereditary gastrointestinal polyposis
Jack Russell Terrier
Germline APC variant
Epidemiology
Variant allele frequency
Breed distribution
Online Access:https://doi.org/10.1186/s12917-022-03338-w

Internet

https://doi.org/10.1186/s12917-022-03338-w

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