Extensive three-dimensional intratumor proteomic heterogeneity revealed by multiregion sampling in high-grade serous ovarian tumor specimens

Extensive three-dimensional intratumor proteomic heterogeneity revealed by multiregion sampling in high-grade serous ovarian tumor specimens

Summary: Enriched tumor epithelium, tumor-associated stroma, and whole tissue were collected by laser microdissection from thin sections across spatially separated levels of ten high-grade serous ovarian carcinomas (HGSOCs) and analyzed by mass spectrometry, reverse phase protein arrays, and RNA seq...

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Bibliographic Details
Main Authors: Allison L. Hunt, Nicholas W. Bateman, Waleed Barakat, Sasha Makohon-Moore, Brian L. Hood, Kelly A. Conrads, Ming Zhou, Valerie Calvert, Mariaelena Pierobon, Jeremy Loffredo, Tracy J. Litzi, Julie Oliver, Dave Mitchell, Glenn Gist, Christine Rojas, Brian Blanton, Emma L. Robinson, Kunle Odunsi, Anil K. Sood, Yovanni Casablanca, Kathleen M. Darcy, Craig D. Shriver, Emanuel F. Petricoin, Uma N.M. Rao, G. Larry Maxwell, Thomas P. Conrads
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:iScience
Subjects:
Oncology
Cancer systems biology
Proteomics
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221007252

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http://www.sciencedirect.com/science/article/pii/S2589004221007252

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