Development of an Intranasal In Situ System for Ribavirin Delivery: In Vitro and In Vivo Evaluation

Development of an Intranasal In Situ System for Ribavirin Delivery: In Vitro and In Vivo Evaluation

Recently, ribavirin has demonstrated effectiveness in treating glioblastoma through intranasal administration utilizing the nose-to-brain delivery route. Enhancing ribavirin’s bioavailability can be achieved by utilizing intranasal stimuli-responsive systems that create a gel on the nasal mucosa. Th...

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Bibliographic Details
Main Authors: Iosif B. Mikhel, Elena O. Bakhrushina, Danila A. Petrusevich, Andrey A. Nedorubov, Svetlana A. Appolonova, Natalia E. Moskaleva, Natalia B. Demina, Svetlana I. Kosenkova, Mikhail A. Parshenkov, Ivan I. Krasnyuk
Format: Article
Language:English
Published: MDPI AG 2024-08-01
Series:Pharmaceutics
Subjects:
intranasal administration
in situ systems
ribavirin
nose-to-brain mechanism
cancer
anticancer therapy
Online Access:https://www.mdpi.com/1999-4923/16/9/1125

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https://www.mdpi.com/1999-4923/16/9/1125

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