An in silico pipeline to filter the Toxoplasma gondii proteome for proteins that could traffic to the host cell nucleus and influence host cell epigenetic regulation

An in silico pipeline to filter the Toxoplasma gondii proteome for proteins that could traffic to the host cell nucleus and influence host cell epigenetic regulation

Toxoplasma gondii uses epigenetic mechanisms to regulate both endogenous and host cell gene expression. To identify genes with putative epigenetic functions, we developed an in silico pipeline to interrogate the T. gondii proteome of 8313 proteins. Step 1 employs PredictNLS and NucPred to identify g...

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Bibliographic Details
Main Authors: Genevieve Syn, Jenefer M Blackwell, Sarra E Jamieson, Richard W Francis
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2018-05-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
Toxoplasma gondii
nuclear localisation
epigenetics
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018000600401&lng=en&tlng=en

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018000600401&lng=en&tlng=en

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