Royal jelly coordinately enhances hippocampal neuronal expression of somatostatin and neprilysin genes conferring neuronal protection against toxic soluble amyloid-β oligomers implicated in Alzheimer’s disease pathogenesis

Royal jelly coordinately enhances hippocampal neuronal expression of somatostatin and neprilysin genes conferring neuronal protection against toxic soluble amyloid-β oligomers implicated in Alzheimer’s disease pathogenesis

Hippocampal somatostatin (SST)-neprilysin (NEP) system functions as a defense system against neurotoxic soluble amyloid-β oligomers associated with onset of Alzheimer’s disease. However, it remains unknown whether royal jelly (RJ) could impact the defense system. In this study using primary cultures...

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Bibliographic Details
Main Authors: Ichiro Kawahata, Huinan Xu, Michiyo Takahashi, Kiyoshi Murata, Wanying Han, Yoshihisa Yamaguchi, Akira Fujii, Kikuji Yamaguchi, Tohru Yamakuni
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Journal of Functional Foods
Subjects:
Royal jelly
CREB
CRE-mediated transcription
Somatostatin
Neprilysin
Hippocampal neurons
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464618305255

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http://www.sciencedirect.com/science/article/pii/S1756464618305255

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